Cuboid syndrome is usually an overuse injury that tends to occur more often in athletes, but it can follow an acute ankle injury. It the cuboid fault syndrome or a subluxed cuboid. It is thought to be due to the pull of the peroneus longus tendon trying to sublux the cuboid from the joints around it.

The pain is usually over the lateral side of the foot that gets worse with increased weight bearing activity. Some foot types, especially a pronated foot are more at risk for this. Some athletes who do a lot of jumping (such as ballet) or lateral motion (such as tennis) are also at greater risk. Initially, some also describe non-specific complaint of the foot feeling weaker, usually when trying to push off the ground. With experience, it is often possible to feel less movement of the affected cuboid compared to the other side. This is thought to be due to the cuboid being subluxed out of its normal alignment.

Initial treatment of cuboid syndrome is to use of some type of strapping to make the cuboid more stable so it can be an effective pulley for the peroneus longus tendon. Some may need pain relief with ICE or anti-inflammatory medication. As the cuboid may be subluxed, a cuboid manipulation is often used to place the bone in a better alignment. Foot orthotics are usually used long tern to help improve foot function and make the cuboid more stable in the joints that surround it.